ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate

Base Information

• Chemical Name: ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate
• CAS No.: 1414380-11-2
• Molecular Formula: C₁₅H₂₀ClNO₄
• Molecular Weight: 313.781
• Mol file: 1414380-11-2.mol

Synonyms:ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate

Chemical Property of ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate

There total 3 articles about ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3-chloro-4-methoxyphenethylamine (7569-87-1) + ethyl 3-(chloroformyl)propionate (14794-31-1,97900-84-0) → ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate (1414380-11-2)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2012.09.033

Reference yield:

3-chloro-4-methoxy-benzaldehyde (4903-09-7) → ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate (1414380-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / acetic acid / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / Reflux; Inert atmosphere

3: sodium hydroxide / dichloromethane; water / 0 - 20 °C

With lithium aluminium tetrahydride; ammonium acetate; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid;

DOI:10.1016/j.bmc.2012.09.033

Reference yield:

3-chloro-4-methoxy-β-nitrostyrene (58776-06-0) → ethyl [β-(3-chloro-4-methoxy)phenethylamino]-oxobutanoate (1414380-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / Reflux; Inert atmosphere

2: sodium hydroxide / dichloromethane; water / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water;

DOI:10.1016/j.bmc.2012.09.033

upstream raw materials:

3-chloro-4-methoxyphenethylamine

ethyl 3-(chloroformyl)propionate

3-chloro-4-methoxy-β-nitrostyrene

3-chloro-4-methoxy-benzaldehyde