N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide

Base Information

• Chemical Name: N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide
• CAS No.: 500227-33-8
• Molecular Formula: C₁₈H₁₈F₃NO₃
• Molecular Weight: 353.341

Synonyms:N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide

Chemical Property of N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide

Chemical Property:

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Technology Process of N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide

There total 2 articles about N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

trifluoroacetic anhydride (407-25-0) + N-(4-methoxy-benzyl)-2-(2-oxo-cyclohexyl)-acetamide (500227-32-7) → N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide (500227-33-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/jo0341970

Reference yield:

4-methoxy-benzylamine (2393-23-9) → N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide (500227-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / EDCI; DMAP / CH₂Cl₂ / 2 h / 20 °C

2: 79 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1021/jo0341970

Reference yield: 19.0%

N-(4-methoxy-benzyl)-N-(4,5,6,7-tetrahydro-benzofuran-2-yl)-2,2,2-trifluoro acetamide (500227-33-8) → 7a-hydroxy-1-(4-methoxy-benzyl)-1,4,5,6,7,7a-hexahydro-indol-2-one

Guidance literature:

With potassium carbonate; In methanol; water; for 2h; Heating;

DOI:10.1021/jo0341970

upstream raw materials:

trifluoroacetic anhydride

N-(4-methoxy-benzyl)-2-(2-oxo-cyclohexyl)-acetamide

4-methoxy-benzylamine

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