2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol

Base Information

Chemical Name:2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol
CAS No.:1376514-08-7
Molecular Formula:C₂₂H₃₅N₅O₂
Molecular Weight:401.552
Hs Code.:

Synonyms:2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol

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Chemical Property of 2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol

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Technology Process of 2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol

There total 10 articles about 2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-38-3
(2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol

: 1376514-08-7
2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

: 139102-34-4
methyl 4-bromo-2-methoxybenzoate

: 1376514-08-7
2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium borohydride; ethanol / tetrahydrofuran / 18 h

2.1: phosphorus tribromide / dichloromethane / 0.67 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

3.2: 16 h / 70 °C

4.1: methanol / 16 h / 65 °C

5.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

6.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 24 h / Reflux

7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 2250.23 Torr

8.1: trifluoroacetic acid / propyl cyanide / 30 h / 120 °C

9.1: dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / 60 °C

9.2: 8 h / 20 - 60 °C / Inert atmosphere

10.1: boron tribromide / dichloromethane / 3 h / 20 °C / Cooling with ice

With 1,4-diaza-bicyclo[2.2.2]octane; lithium borohydride; ethanol; dimethylsulfide borane complex; hydrogen; boron tribromide; phosphorus tribromide; sodium hydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; propyl cyanide; ethanol; dichloromethane; ethyl acetate; mineral oil;

Reference yield:

: 17102-63-5
(4-bromo-2-methoxyphenyl)methanol

: 1376514-08-7
2-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-[3-(dimethylamino)propyl]phenol

Guidance literature:: Multi-step reaction with 9 steps

1.1: phosphorus tribromide / dichloromethane / 0.67 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 16 h / 70 °C

3.1: methanol / 16 h / 65 °C

4.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

5.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 24 h / Reflux

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 2250.23 Torr

7.1: trifluoroacetic acid / propyl cyanide / 30 h / 120 °C

8.1: dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / 60 °C

8.2: 8 h / 20 - 60 °C / Inert atmosphere

9.1: boron tribromide / dichloromethane / 3 h / 20 °C / Cooling with ice

With 1,4-diaza-bicyclo[2.2.2]octane; dimethylsulfide borane complex; hydrogen; boron tribromide; phosphorus tribromide; sodium hydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; propyl cyanide; ethanol; dichloromethane; ethyl acetate; mineral oil;