(2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol

Base Information

Chemical Name:(2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol
CAS No.:1376514-38-3
Molecular Formula:C₂₃H₃₇N₅O₂
Molecular Weight:415.579
Hs Code.:

Synonyms:(2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol

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Chemical Property of (2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol

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Technology Process of (2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol

There total 9 articles about (2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-37-2
3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

: 1376514-38-3
(2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol

Guidance literature:: 3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate; With dimethylsulfide borane complex; In tetrahydrofuran; at 60 ℃; for 0.5h;

With N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; at 20 - 60 ℃; for 8h; Inert atmosphere;

Reference yield:

: 854778-42-0
4-bromo-1-(bromomethyl)-2-methoxybenzene

: 1376514-38-3
(2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 70 °C

2.1: methanol / 16 h / 65 °C

3.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

4.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 24 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 2250.23 Torr

6.1: trifluoroacetic acid / propyl cyanide / 30 h / 120 °C

7.1: dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / 60 °C

7.2: 8 h / 20 - 60 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; dimethylsulfide borane complex; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; propyl cyanide; ethanol; ethyl acetate; mineral oil;

Reference yield:

: 17102-63-5
(4-bromo-2-methoxyphenyl)methanol

: 1376514-38-3
(2S)-2-[(2-amino-5-{4-[3-(dimethylamino)propyl]-2-methoxybenzyl}-6-methyl-pyrimidin-4-yl)amino]pentan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus tribromide / dichloromethane / 0.67 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 16 h / 70 °C

3.1: methanol / 16 h / 65 °C

4.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

5.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 24 h / Reflux

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 2250.23 Torr

7.1: trifluoroacetic acid / propyl cyanide / 30 h / 120 °C

8.1: dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / 60 °C

8.2: 8 h / 20 - 60 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; dimethylsulfide borane complex; hydrogen; phosphorus tribromide; sodium hydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; propyl cyanide; ethanol; dichloromethane; ethyl acetate; mineral oil;