5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

Base Information

Chemical Name:5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester
CAS No.:363602-33-9
Molecular Formula:C₆₀H₅₆N₆O₁₃
Molecular Weight:1069.14
Hs Code.:

5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

Synonyms:5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

Suppliers and Price of 5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

There total 10 articles about 5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-1-tert-butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

: 363602-33-9
5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 2h;
DOI:10.1021/ol016158l

Reference yield:

: 363602-32-8
BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]3-OAll

: 363602-33-9
5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DMDPd; morpholine / tetrahydrofuran / 0.5 h / 20 °C

2: 3.10 g / HCl / dioxane / 2 h / 0 °C

With morpholine; hydrogenchloride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/ol016158l

Reference yield:

: 5-[(1-tert-butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

: 363602-33-9
5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PyCloP; DIEA / CH₂Cl₂

2: DMDPd; morpholine / tetrahydrofuran / 0.5 h / 20 °C

3: 3.10 g / HCl / dioxane / 2 h / 0 °C

With morpholine; hydrogenchloride; N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/ol016158l