{(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

Base Information

Chemical Name:{(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate
CAS No.:955967-89-2
Molecular Formula:C₂HF₃O₂*C₄₂H₄₄N₁₀O₅
Molecular Weight:882.899
Hs Code.:

{(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

Synonyms:{(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

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Chemical Property of {(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

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Technology Process of {(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

There total 5 articles about {(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955381-15-4
((1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl)-carbamic acid benzyl ester

: 15268-31-2
3-Pyridyl isocyanate

: 76-05-1
trifluoroacetic acid

: 955967-89-2
{(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

Guidance literature:: ((1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl)-carbamic acid benzyl ester; 3-Pyridyl isocyanate; With triethylamine; In tetrahydrofuran; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 955381-15-4
((1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl)-carbamic acid benzyl ester

: 76-05-1
trifluoroacetic acid

: 955967-89-2
{(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

Guidance literature:: ((1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl)-carbamic acid benzyl ester; 3-Pyridyl isocyanate; With triethylamine; In tetrahydrofuran; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1001416-61-0
C₄₀H₃₇ClN₆O₆

: 955967-89-2
{(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / acetonitrile / 1 h / 160 °C / Microwave irradiation

2: hydrogenchloride; water / dichloromethane

3: hydrogenchloride; methanol / 1,4-dioxane / 2 h / 20 °C

4: triethylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; methanol; water; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;