1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea

Base Information

Chemical Name:1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea
CAS No.:955381-19-8
Molecular Formula:C₃₄H₃₈N₁₀O₃
Molecular Weight:634.741
Hs Code.:

Synonyms:1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea

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Chemical Property of 1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea

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Technology Process of 1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea

There total 5 articles about 1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955967-89-2
{(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl)-2,3-dihydroxy-cyclopentyl}-carbamic acid benzyl ester trifluoroacetate

: 955381-19-8
1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol;

Reference yield:

: 955381-15-4
((1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl)-carbamic acid benzyl ester

: 955381-19-8
1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol

With hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;

Reference yield:

: 1001416-61-0
C₄₀H₃₇ClN₆O₆

: 955381-19-8
1-((R)-1-[9-((1R,2S,3R,4S)-4-amino-2,3-dihydroxy-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl)-3-pyridin-3-yl-urea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium iodide / acetonitrile / 1 h / 160 °C / Microwave irradiation

2: hydrogenchloride; water / dichloromethane

3: hydrogenchloride; methanol / 1,4-dioxane / 2 h / 20 °C

4: triethylamine / tetrahydrofuran / 20 °C

5: hydrogen / palladium 10% on activated carbon / ethanol

With hydrogenchloride; methanol; water; hydrogen; triethylamine; sodium iodide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile;