3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid

Base Information

• Chemical Name: 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid
• CAS No.: 1391595-61-1
• Molecular Formula: C₃₂H₃₁NO₄S
• Molecular Weight: 525.668
• Mol file: 1391595-61-1.mol

Synonyms:3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid

Chemical Property of 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid

There total 5 articles about 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoate (1391595-57-5) → 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid (1391595-61-1)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1002/cbic.201200579

Reference yield:

3-amino-4-methyl benzoic acid methyl ester (18595-18-1) → 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid (1391595-61-1)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 72 h / Reflux

2: N-Bromosuccinimide / tetrachloromethane / 3 h / UV-irradiation

3: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

4: lithium hydroxide; water / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cbic.201200579

Reference yield:

3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester (330807-44-8) → 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoic acid (1391595-61-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / tetrachloromethane / 3 h / UV-irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

3: lithium hydroxide; water / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cbic.201200579

upstream raw materials:

methyl 3-((tert-butoxycarbonyl)amino)-4-((tritylthio)methyl)benzoate

3-amino-4-methyl benzoic acid methyl ester

3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester

methyl 4-(bromomethyl)-3-[(tert-butyloxycarbonyl)amino]benzoate

Downstream raw materials:

C₄₄H₄₇N₃O₆S