3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester

Base Information

• Chemical Name: 3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester
• CAS No.: 330807-44-8
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.309
• Mol file: 330807-44-8.mol

Synonyms:3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester

Chemical Property of 3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester

There total 1 articles about 3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-amino-4-methyl benzoic acid methyl ester (18595-18-1) → 3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester (330807-44-8)

Guidance literature:

In tetrahydrofuran; for 72h; Reflux;

DOI:10.1021/acschembio.5b00119

Reference yield: 95.0%

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-11-1) + 3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester (330807-44-8) → N-(2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)carbamic acid tert-butyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at -10 - 0 ℃; Reagent/catalyst; Solvent; Temperature;

Reference yield: 89.0%

3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester (330807-44-8) → methyl 4-(bromomethyl)-3-[(tert-butyloxycarbonyl)amino]benzoate (330807-46-0)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 8h; Irradiation;

DOI:10.1002/ejoc.201301517

upstream raw materials:

di-tert-butyl dicarbonate

3-amino-4-methyl benzoic acid methyl ester

Downstream raw materials:

methyl 4-(bromomethyl)-3-[(tert-butyloxycarbonyl)amino]benzoate

methyl 3-[(tert-butyloxycarbonyl)amino]-4-(methoxymethyl)benzoate

benzyl 3-[(tert-butyloxycarbonyl)amino]-4-(methoxymethyl)benzoate

3-[(tert-butyloxycarbonyl)amino]-4-methylbenzoic acid