N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine

Base Information

• Chemical Name: N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine
• CAS No.: 131925-11-6
• Molecular Formula: C₁₅H₁₇N₃O₃
• Molecular Weight: 287.318
• Mol file: 131925-11-6.mol

Synonyms:N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine

Chemical Property of N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine

There total 1 articles about N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + N-methyl-N-(2-aminophenyl)-1H-pyrrol-1-ylamine (87948-04-7) → N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine (131925-11-6)

Guidance literature:

In tetrahydrofuran; for 15h; Ambient temperature;

Reference yield:

N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine (131925-11-6) → [9-(4-Chloro-benzoyl)-4-methyl-9,10-dihydro-4H-3a,4,9-triaza-benzo[f]azulen-10-yl]-acetic acid (131925-00-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / POCl₃ / CH₂Cl₂ / 20 h / Heating

2: 90 percent / NaBH₃CN, HCl / ethanol; tetrahydrofuran / 20 h / Ambient temperature

3: 66 percent / Et₃N / tetrahydrofuran / 72 h / Heating

4: 78 percent / 1N aq. KOH / ethanol / 24 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium cyanoborohydride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

N-(2-Methoxycarbonylacetamidophenyl)-N-methyl-1H-pyrrol-1-ylamine (131925-11-6) → methyl 10,11-dihydro-5-methyl-10-benzoyl-5H-pyrrolo[1,2-b][1,2,5]benzotriazepine-11-acetate (131925-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / POCl₃ / CH₂Cl₂ / 20 h / Heating

2: 90 percent / NaBH₃CN, HCl / ethanol; tetrahydrofuran / 20 h / Ambient temperature

3: 69 percent / Et₃N / tetrahydrofuran / 72 h / Heating

With hydrogenchloride; sodium cyanoborohydride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

3-chloro-3-oxopropanoic acid methyl ester

N-methyl-N-(2-aminophenyl)-1H-pyrrol-1-ylamine

Downstream raw materials:

5-Methyl-10-benzoyl-10,11-dihydro-5H-pyrrolo<1,2-b><1,2,5>benzotriazepine-11-acetic acid

[4-Methyl-9-(4-methyl-benzoyl)-9,10-dihydro-4H-3a,4,9-triaza-benzo[f]azulen-10-yl]-acetic acid

[9-(4-Chloro-benzoyl)-4-methyl-9,10-dihydro-4H-3a,4,9-triaza-benzo[f]azulen-10-yl]-acetic acid

methyl 10,11-dihydro-5-methyl-10-benzoyl-5H-pyrrolo[1,2-b][1,2,5]benzotriazepine-11-acetate