{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester

Base Information

Chemical Name:{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester
CAS No.:1315469-19-2
Molecular Formula:C₂₇H₂₅Cl₂N₃O₅
Molecular Weight:542.419
Hs Code.:

Synonyms:{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester

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Chemical Property of {2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester

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Technology Process of {2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester

There total 11 articles about {2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1315469-18-1
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxy-phenoxy)-pyridin-3-yl]-methanone

: 105-36-2
ethyl bromoacetate

: 1315469-19-2
{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester

Guidance literature:: (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxy-phenoxy)-pyridin-3-yl]-methanone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h;

ethyl bromoacetate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1315469-19-2
{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 19 h / 20 - 30 °C

2.1: triethylamine / dichloromethane / 72 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 900.09 Torr

4.1: triphenylphosphine / N,N-dimethyl-formamide / 4 h / 135 °C

5.1: borane-THF / tetrahydrofuran / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 20 °C

7.1: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / 1.55 h / -75 °C / Dry ice bath

7.2: 21 h / 0 - 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

8.2: 3 h / 20 °C

With n-butyllithium; borane-THF; Triisopropyl borate; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1940-42-7,79151-08-9
4-bromo-2,5-dichlorophenol

: 1315469-19-2
{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-phenoxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tetrakis(actonitrile)copper(I) hexafluorophosphate / o-xylene / 16 h / 120 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 20 °C

3.1: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / 1.55 h / -75 °C / Dry ice bath

3.2: 21 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

4.2: 3 h / 20 °C

With n-butyllithium; Triisopropyl borate; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(actonitrile)copper(I) hexafluorophosphate; In tetrahydrofuran; hexane; o-xylene; N,N-dimethyl-formamide; mineral oil;