1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester
• CAS No.: 1208334-62-6
• Molecular Formula: C₂₀H₁₈ClNO₂
• Molecular Weight: 339.821

Synonyms:1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester

Chemical Property of 1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester

There total 3 articles about 1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

nitromethane (75-52-5) + 4-chlorobenzaldehyde (104-88-1) + acetoacetic acid methyl ester (105-45-3) + benzylamine (100-46-9) → 1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester (1208334-62-6)

Guidance literature:

With nickel(II) ferrite; In neat (no solvent); at 100 ℃; for 4h; Green chemistry;

DOI:10.1039/c4ra09348h

Reference yield: 83.0%

1-chloro-4-(2-nitrovinyl)benzene (706-07-0,5153-70-8) + acetoacetic acid methyl ester (105-45-3) + benzylamine (100-46-9) → 1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester (1208334-62-6)

Guidance literature:

With 3-methyl-2-(1-sulfobutyl)-1H-imidazolium hydrogen sulfate; In ethanol; for 12h; Reflux; Green chemistry;

DOI:10.1515/znb-2014-0108

Reference yield: 78.0%

4-chlorobenzaldehyde (104-88-1) + acetoacetic acid methyl ester (105-45-3) + benzylamine (100-46-9) → 1-benzyl-4-(4-chloro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methyl ester (1208334-62-6)

Guidance literature:

With nitromethane; copper(II) oxide; at 100 - 105 ℃; for 12h; Green chemistry;

DOI:10.1016/j.crci.2013.02.008

upstream raw materials:

nitromethane

4-chlorobenzaldehyde

acetoacetic acid methyl ester

benzylamine

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