2-[(Methoxymethyl)oxy]-4-methyl-beta-cyclopropylidenebenzeneethanol

Base Information

Chemical Name:2-[(Methoxymethyl)oxy]-4-methyl-beta-cyclopropylidenebenzeneethanol
CAS No.:154698-96-1
Molecular Formula:C₁₄H₁₈O₃
Molecular Weight:234.295
Hs Code.:
DSSTox Substance ID:DTXSID001186269
Nikkaji Number:J575.627H

Synonyms:DTXSID001186269;beta-Cyclopropylidene-2-(methoxymethoxy)-4-methylbenzeneethanol;2-[(Methoxymethyl)oxy]-4-methyl-beta-cyclopropylidenebenzeneethanol;154698-96-1

Suppliers and Price of 2-[(Methoxymethyl)oxy]-4-methyl-beta-cyclopropylidenebenzeneethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(Methoxymethyl)oxy]-4-methyl-beta-cyclopropylidenebenzeneethanol

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:234.125594432
Heavy Atom Count:17
Complexity:279

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)C(=C2CC2)CO)OCOC

Technology Process of 2-[(Methoxymethyl)oxy]-4-methyl-beta-cyclopropylidenebenzeneethanol

There total 3 articles about 2-[(Methoxymethyl)oxy]-4-methyl-beta-cyclopropylidenebenzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 154698-95-0
1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-<2-<(methoxymethyl)oxy>-4-methylphenyl>ethane

: 154698-96-1
2-Cyclopropylidene-2-<2-<(methoxymethyl)oxy>-4-methylphenyl>ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1021/jo00080a014

Reference yield:

: 57234-27-2
1-(methoxymethoxy)-3-methylbenzene

: 154698-96-1
2-Cyclopropylidene-2-<2-<(methoxymethyl)oxy>-4-methylphenyl>ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / t-BuLi / diethyl ether; hexane / 0 °C / 1.) 2 h, 2.) 1 h

2: 94 percent / NaH / tris<2-(2-methoxyethoxy)ethyl>amine / tetrahydrofuran / 62 °C / 1.) 10 h, 2.) 1 h

3: 100 percent / n-Bu₄N⁽¹⁺⁾*F^(1-) / tetrahydrofuran / 3 h / Ambient temperature

With tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium hydride; Tris(3,6-dioxaheptyl)amine; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/jo00080a014

Reference yield:

: 154698-94-9
(tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone

: 154698-96-1
2-Cyclopropylidene-2-<2-<(methoxymethyl)oxy>-4-methylphenyl>ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NaH / tris<2-(2-methoxyethoxy)ethyl>amine / tetrahydrofuran / 62 °C / 1.) 10 h, 2.) 1 h

2: 100 percent / n-Bu₄N⁽¹⁺⁾*F^(1-) / tetrahydrofuran / 3 h / Ambient temperature

With tetrabutyl ammonium fluoride; sodium hydride; Tris(3,6-dioxaheptyl)amine; In tetrahydrofuran;
DOI:10.1021/jo00080a014