methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Base Information

Chemical Name:methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
CAS No.:916913-67-2
Molecular Formula:C₂₅H₂₅ClF₃NO₆S
Molecular Weight:559.991
Hs Code.:

Synonyms:methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

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Chemical Property of methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

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Technology Process of methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

There total 4 articles about methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 913078-78-1
N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

: 74733-30-5
methyl 4-Bromomethyl-3-chlorobenzoate

: 916913-67-2
methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: With potassium carbonate; In acetone; at 50 ℃; for 7h;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 3-chloro-4-methylphenyl trifluoromethanesulfonate

: 916913-67-2
methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 100 percent / N-bromosuccinimide; benzoyl perbromide / CCl₄ / 5 h / Heating

3: 81 percent / potassium carbonate / acetone / 7 h / 50 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; N-Bromosuccinimide; Pentabrombenzoylbromid; potassium carbonate; triethylamine; palladium diacetate; In tetrachloromethane; dimethyl sulfoxide; acetone;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 615-62-3
3-chloro-4-methylphenol

: 916913-67-2
methyl 3-chloro-4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 4 h / 20 °C

2: triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 100 percent / N-bromosuccinimide; benzoyl perbromide / CCl₄ / 5 h / Heating

4: 81 percent / potassium carbonate / acetone / 7 h / 50 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; N-Bromosuccinimide; Pentabrombenzoylbromid; potassium carbonate; triethylamine; palladium diacetate; In tetrachloromethane; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1016/j.bmc.2006.08.001