N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Base Information

Chemical Name:N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide
CAS No.:913078-78-1
Molecular Formula:C₁₆H₁₈F₃NO₄S
Molecular Weight:377.384
Hs Code.:

Synonyms:N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Chemical Property:

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Technology Process of N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

There total 8 articles about N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 913078-77-0
N-isobutyl-N-[2-(methoxymethoxy)-4-(trifluoromethyl)phenyl]-5-methylfuran-2-sulfonamide

: 913078-78-1
N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; for 6h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 209688-18-6
2-nitro-5-trifluoromethylphenyl methoxymethyl ether

: 913078-78-1
N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 402-17-5
2-nitro-5-trifluoromethylphenol

: 913078-78-1
N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067