methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Base Information

Chemical Name:methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate
CAS No.:1055320-82-5
Molecular Formula:C₃₁H₄₂ClNO₄Si
Molecular Weight:556.217
Hs Code.:

Synonyms:methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

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Chemical Property of methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

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Technology Process of methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

There total 8 articles about methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1055320-83-6
methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1055320-82-5
methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Guidance literature:: methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate; With sodium hydride; In dimethyl sulfoxide; for 0.333333h;

2-(tert-butyldimethylsilyloxy)ethyl bromide; With potassium iodide; In dimethyl sulfoxide; at 20 ℃;

With hydrogenchloride; water; In dimethyl sulfoxide;

Reference yield:

: 1055320-72-3
7-chloro-1H-indole-6-carboxylic acid

: 1055320-82-5
methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux

1.2: 20 °C

2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

3.2: 0.25 h

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 18 h / 70 °C

6.1: sodium hydride / dimethyl sulfoxide / 0.33 h

6.2: 20 °C

With hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;

Reference yield:

: 1055320-74-5
7-chloro-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1055320-82-5
methyl-1-(2-(tert-butyldimethylsilyloxy)ethyl)-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

1.2: 0.25 h

2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 18 h / 70 °C

4.1: sodium hydride / dimethyl sulfoxide / 0.33 h

4.2: 20 °C

With pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;