methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Base Information

Chemical Name:methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate
CAS No.:1055320-83-6
Molecular Formula:C₂₃H₂₄ClNO₃
Molecular Weight:397.901
Hs Code.:

Synonyms:methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

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Chemical Property of methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Chemical Property:

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Technology Process of methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

There total 7 articles about methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1055320-76-7
methyl 2-bromo-7-chloro-3-cyclohexyl-1H-indole-6-carboxylate

: 5720-07-0
4-methoxyphenylboronic acid

: 1055320-83-6
methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Guidance literature:: With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 70 ℃; for 18h;

Reference yield:

: 1055320-72-3
7-chloro-1H-indole-6-carboxylic acid

: 1055320-83-6
methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux

1.2: 20 °C

2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

3.2: 0.25 h

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 18 h / 70 °C

With hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene; benzene;

Reference yield:

: 1055320-73-4
7-chloro-3-cyclohexenyl-1H-indole-6-carboxylic acid

: 1055320-83-6
methyl-7-chloro-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

2.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

2.2: 0.25 h

3.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

4.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 18 h / 70 °C

With hydrogen; pyridinium hydrobromide perbromide; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene; benzene;