(S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

Base Information

• Chemical Name: (S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol
• CAS No.: 1330032-44-4
• Molecular Formula: C₁₄H₂₁N₃O₄
• Molecular Weight: 295.338
• Mol file: 1330032-44-4.mol

Synonyms:(S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

Chemical Property of (S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

There total 1 articles about (S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-methoxy-4-(piperazin-1-yl)nitrobenzene + (S)-Propylene oxide (16088-62-3) → (S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol (1330032-44-4)

Guidance literature:

2-methoxy-4-(piperazin-1-yl)nitrobenzene; (S)-Propylene oxide; In methanol; at 20 ℃; Sealed tube;

With N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 48h; Sealed tube;

DOI:10.1021/jm200758k

Reference yield:

(S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol (1330032-44-4) → (S)-1-[4-(4-amino-3-methoxyphenyl)-piperazin-1-yl]-propan-2-ol (1233144-09-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 1h; under 2585.81 Torr;

DOI:10.1021/jm200758k

Reference yield:

(S)-1-[4-(3-methoxy-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol (1330032-44-4) → (S)-1-(4-{3-methoxy-4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol (1233144-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 2585.81 Torr

2: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; aniline; In 1-methyl-pyrrolidin-2-one; methanol;

DOI:10.1021/jm200758k

upstream raw materials:

(S)-Propylene oxide

Downstream raw materials:

(S)-1-(4-{3-methoxy-4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol

N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide

(S)-1-[4-(4-amino-3-methoxyphenyl)-piperazin-1-yl]-propan-2-ol