N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide

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Chemical Name:N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide
CAS No.:1233184-10-5
Molecular Formula:C₂₈H₃₅N₇O₄S
Molecular Weight:565.696
Hs Code.:

Synonyms:N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide

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Chemical Property of N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide

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Technology Process of N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide

There total 7 articles about N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide trifluoroacetic acid

: 1233184-10-5
N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide

Guidance literature:: With sodium hydrogencarbonate; In water;
DOI:10.1021/jm200758k

Reference yield:

: 756520-78-2
(2-(methylsulfonyl)aminophenyl)boronic acid

: 1233184-10-5
N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

4.2: 0.08 h

5.1: sodium hydrogencarbonate / water

With palladium diacetate; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; aniline; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1021/jm200758k

Reference yield:

: 1233094-95-5
7-bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1233184-10-5
N-[2-(2-{4-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-2-methoxy-phenylamino}-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

4.2: 0.08 h

5.1: sodium hydrogencarbonate / water

With palladium diacetate; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; aniline; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1021/jm200758k