α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Base Information

Chemical Name:α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol
CAS No.:897655-86-6
Molecular Formula:C₂₇H₂₂Br₂O
Molecular Weight:522.279
Hs Code.:

Synonyms:α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Suppliers and Price of α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

There total 4 articles about α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 897655-85-5
1,3-Dibromo-2-(2-ethynyl-phenylethynyl)-benzene

: 938-16-9
2,2-dimethylpropiophenone

: 897655-86-6
α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Guidance literature:: 1,3-Dibromo-2-(2-ethynyl-phenylethynyl)-benzene; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; at 0 ℃; for 0.5h;

2,2-dimethylpropiophenone; In tetrahydrofuran; n-heptane; at 0 - 20 ℃;
DOI:10.1021/ol0605676

Reference yield:

: 1,3-dibromo-2-ethynylbenzene

: 897655-86-6
α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / triethylamine / dichlorobis(triphenylphosphine)palladium; copper(I) iodide / 12 h

2.1: 90 percent / aq. NaOH / diethyl ether; methanol / 10 h / 20 °C

3.1: lithium diisopropylamide / tetrahydrofuran; heptane / 0.5 h / 0 °C

3.2: 74 percent / tetrahydrofuran; heptane / 0 - 20 °C

With sodium hydroxide; triethylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; diethyl ether; n-heptane; 1.1: Sonogashira reaction;
DOI:10.1021/ol0605676

Reference yield:

: 137648-47-6
1-iodo-2-ethynylbenzene

: 897655-86-6
α-[[2-[(2,6-dibromophenyl)ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / triethylamine / dichlorobis(triphenylphosphine)palladium; copper(I) iodide / 12 h

2.1: 90 percent / aq. NaOH / diethyl ether; methanol / 10 h / 20 °C

3.1: lithium diisopropylamide / tetrahydrofuran; heptane / 0.5 h / 0 °C

3.2: 74 percent / tetrahydrofuran; heptane / 0 - 20 °C

With sodium hydroxide; triethylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; diethyl ether; n-heptane; 1.1: Sonogashira reaction;
DOI:10.1021/ol0605676