2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide

Base Information

• Chemical Name: 2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide
• CAS No.: 1272662-48-2
• Molecular Formula: C₃₀H₃₂ClIN₄O₂
• Molecular Weight: 642.967
• Mol file: 1272662-48-2.mol

Synonyms:2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide

Chemical Property of 2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide

There total 3 articles about 2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-iodo-6-methyl-2-phenylpyrimidin-4-ol (83419-12-9) + 5-methylfurfurylamine (14003-16-8) + p-chlorobenzylisocyanide (39546-47-9) + isovaleraldehyde (590-86-3) → 2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide (1272662-48-2)

Guidance literature:

In methanol; at 60 ℃; for 72h;

DOI:10.1039/c0cc04164e

Reference yield:

benzamidin (618-39-3) → 2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide (1272662-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium / ethanol / Reflux

2: iodine; potassium carbonate / tetrahydrofuran / Reflux

3: methanol / 72 h / 60 °C

With iodine; sodium; potassium carbonate; In tetrahydrofuran; methanol; ethanol; 3: Ugi condensation;

DOI:10.1039/c0cc04164e

Reference yield:

6-methyl-2-phenylpyrimidin-4-ol (13514-79-9) → 2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide (1272662-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; potassium carbonate / tetrahydrofuran / Reflux

2: methanol / 72 h / 60 °C

With iodine; potassium carbonate; In tetrahydrofuran; methanol; 2: Ugi condensation;

DOI:10.1039/c0cc04164e

upstream raw materials:

5-iodo-6-methyl-2-phenylpyrimidin-4-ol

5-methylfurfurylamine

p-chlorobenzylisocyanide

isovaleraldehyde

Downstream raw materials:

(E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide