(E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide

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Chemical Name:(E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide
CAS No.:1272662-58-4
Molecular Formula:C₃₀H₃₁ClN₄O₂
Molecular Weight:515.055
Hs Code.:

Synonyms:(E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide

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Chemical Property of (E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide

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Technology Process of (E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide

There total 4 articles about (E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1272662-48-2
2-[(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)-(5-methylfuran-2-ylmethyl)-amino]-4-methylpentanoic acid 4-chlorobenzylamide

: 1272662-58-4
(E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 130 ℃; for 0.333333h; under 9750.98 Torr; Microwave irradiation;
DOI:10.1039/c0cc04164e

Reference yield:

: 83419-12-9
5-iodo-6-methyl-2-phenylpyrimidin-4-ol

: 1272662-58-4
(E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 72 h / 60 °C

2: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 130 °C / 9750.98 Torr / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; 1: Ugi condensation;
DOI:10.1039/c0cc04164e

Reference yield:

: 618-39-3
benzamidin

: 1272662-58-4
(E)-4-methyl-2-[4-methyl-5-(3-oxobut-1-enyl)-2-phenylpyrrolo[2,3-d]pyrimidin-7-yl]-pentanoic acid 4-chlorobenzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium / ethanol / Reflux

2: iodine; potassium carbonate / tetrahydrofuran / Reflux

3: methanol / 72 h / 60 °C

4: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 130 °C / 9750.98 Torr / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; iodine; sodium; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; acetonitrile; 3: Ugi condensation;
DOI:10.1039/c0cc04164e