N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Base Information

Chemical Name:N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide
CAS No.:1186606-04-1
Molecular Formula:C₂₆H₃₄N₄O₅
Molecular Weight:482.58
Hs Code.:

Synonyms:N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Property of N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

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Technology Process of N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

There total 8 articles about N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-14-1
glycolic Acid

: 1186606-02-9
(S)-1-amino-3-{2-ethyl-4-[5-(4-isobutyl-6-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propan-2-ol

: 1186606-04-1
N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1.16667h; Inert atmosphere;
DOI:10.1021/jm4014696

Reference yield:

: 910635-33-5
3-ethyl-N,4-dihydroxy-5-methylbenzimidamide

: 1186606-04-1
N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

1.2: 80 - 100 °C / Inert atmosphere

2.1: sodium hydroxide / water; isopropyl alcohol / 20 °C

3.1: ammonia / methanol / 60 °C / Sealed tube; Inert atmosphere

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.17 h / 20 °C / Inert atmosphere

With ammonia; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm4014696

Reference yield:

: 1186606-00-7
2-ethyl-4-[5-(4-isobutyl-6-methyl-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol

: 1186606-04-1
N-((S)-3-{2-ethyl-4-[5-(4-isobutyl-6-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; isopropyl alcohol / 20 °C

2: ammonia / methanol / 60 °C / Sealed tube; Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.17 h / 20 °C / Inert atmosphere

With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm4014696