1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate

Base Information

Chemical Name:1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate
CAS No.:1356654-14-2
Molecular Formula:C₂₀H₂₇NO₅
Molecular Weight:361.438
Hs Code.:

Synonyms:1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate

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Chemical Property of 1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate

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Technology Process of 1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate

There total 3 articles about 1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141642-82-2
5-oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: C₂₀H₂₉NO₅

: 1356654-14-2
1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; ammonium acetate / tetrachloromethane / 4 h / 75 °C / Irradiation

1.2: 20 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 2.5 h / Inert atmosphere; Reflux

3.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 750.08 Torr

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ammonium acetate; hydrogen; sodium carbonate; In methanol; tetrachloromethane; ethanol; water; toluene; 2.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.11.129

Reference yield:

: 1356654-16-4
1-t-butyl 4-ethyl 6-bromo-5-oxo-2,3,4,5-tetrahydro-1H-azepine-1,4-dicarboxylate

: C₂₀H₂₉NO₅

: 1356654-14-2
1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 2.5 h / Inert atmosphere; Reflux

2: palladium on activated charcoal; hydrogen / methanol / 3 h / 750.08 Torr

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; sodium carbonate; In methanol; ethanol; water; toluene; 1: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.11.129

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: C₂₀H₂₉NO₅

: 1356654-14-2
1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / diethyl ether / -25 - 0 °C

2.1: N-Bromosuccinimide; ammonium acetate / tetrachloromethane / 4 h / 75 °C / Irradiation

2.2: 20 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 2.5 h / Inert atmosphere; Reflux

4.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 750.08 Torr

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; boron trifluoride diethyl etherate; ammonium acetate; hydrogen; sodium carbonate; In methanol; tetrachloromethane; diethyl ether; ethanol; water; toluene; 3.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.11.129