t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate

Base Information

• Chemical Name: t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate
• CAS No.: 1356654-20-0
• Molecular Formula: C₂₀H₂₈N₂O₃
• Molecular Weight: 344.454
• Mol file: 1356654-20-0.mol

Synonyms:t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate

Chemical Property of t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate

There total 11 articles about t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-Butoxybis(dimethylamino)methane (5815-08-7) + t-butyl 4-oxo-3-phenylazepane-1-carboxylate (1356654-15-3) → t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate (1356654-20-0)

Guidance literature:

In 1,2-dimethoxyethane; at 65 ℃; for 21h;

DOI:10.1016/j.tetlet.2011.11.129

Reference yield:

methyl 4-(t-butoxycarbonyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate (1356654-18-6) → t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate (1356654-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 2.5 h / -78 - 20 °C / Inert atmosphere; Sealed vessel

1.2: 3 h / 80 °C

2.1: 1,2-dimethoxyethane / 21 h / 65 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; 1.1: Dieckmann condensation;

DOI:10.1016/j.tetlet.2011.11.129

Reference yield:

1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate (1356654-14-2) → t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate (1356654-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / Reflux

2: 1,2-dimethoxyethane / 21 h / 65 °C

With sodium hydroxide; In 1,2-dimethoxyethane; ethanol;

DOI:10.1016/j.tetlet.2011.11.129

upstream raw materials:

1-t-butyl 4-ethyl 5-oxo-6-phenylazepane-1,4-dicarboxylate

1-t-butyl 4-ethyl 6-bromo-5-oxo-2,3,4,5-tetrahydro-1H-azepine-1,4-dicarboxylate

methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate

methyl 4-(t-butoxycarbonyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate