1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine

Base Information

Chemical Name:1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine
CAS No.:1373355-98-6
Molecular Formula:C₂₇H₂₆F₃N₃O₂S
Molecular Weight:513.584
Hs Code.:

Synonyms:1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine

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Chemical Property of 1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine

There total 4 articles about 1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1373356-65-0
4-(3-(trifluoromethyl)benzyl)benzoic acid

: 1373356-75-2
(4-(azetidin-3-yl)piperidin-1-yl)(thiazol-2-yl)methanone mono-trifluoroacetate

: 1373355-98-6
1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine

Guidance literature:: 4-(3-(trifluoromethyl)benzyl)benzoic acid; (4-(azetidin-3-yl)piperidin-1-yl)(thiazol-2-yl)methanone mono-trifluoroacetate; With triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

With HATU; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1373355-98-6
1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 3 h / 80 °C

2.1: sodium hydroxide / ethanol; water / 20 h / 20 °C

3.1: triethylamine / dichloromethane / 0.33 h / 20 °C

3.2: 20 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 1373355-98-6
1-(1,3-thiazol-2-ylcarbonyl)-4-[1-({4-[3-(trifluoromethyl)benzyl]phenyl}carbonyl)azetidin-3-yl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 3 h / 80 °C

2.1: sodium hydroxide / ethanol; water / 20 h / 20 °C

3.1: triethylamine / dichloromethane / 0.33 h / 20 °C

3.2: 20 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;