Ac-Tyr-Asp(CH₂Cat)-Gly-Phe-CH₂Cat

Base Information

• Chemical Name: Ac-Tyr-Asp(CH₂Cat)-Gly-Phe-CH₂Cat
• CAS No.: 849367-11-9
• Molecular Formula: C₄₀H₄₄N₆O₁₁
• Molecular Weight: 784.823
• Mol file: 849367-11-9.mol

Synonyms:Ac-Tyr-Asp(CH₂Cat)-Gly-Phe-CH₂Cat

Chemical Property of Ac-Tyr-Asp(CH₂Cat)-Gly-Phe-CH₂Cat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ac-Tyr-Asp(CH₂Cat)-Gly-Phe-CH₂Cat

There total 6 articles about Ac-Tyr-Asp(CH₂Cat)-Gly-Phe-CH₂Cat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

Ac-Tyr(tBu)-Asp(CH2Ver)-Gly-Phe-CH2Ver (849367-14-2) → Ac-Tyr-Asp(CH2Cat)-Gly-Phe-CH2Cat (849367-11-9)

Guidance literature:

With aluminium trichloride; In various solvent(s); at 0 ℃;

DOI:10.1055/s-2004-834914

Reference yield:

2,3-dimethoxybenzyl amine (4393-09-3) → Ac-Tyr-Asp(CH2Cat)-Gly-Phe-CH2Cat (849367-11-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-diisopropylethylamine; HBTU / acetonitrile / 0.5 h

1.2: 72 percent / acetonitrile / 72 h

2.1: 85 percent / HCl / diethyl ether / 0.5 h

3.1: 18 percent / AlCl₃ / various solvent(s) / 0 °C

With hydrogenchloride; aluminium trichloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In diethyl ether; acetonitrile;

DOI:10.1055/s-2004-834914

Reference yield:

Fmoc-Asp-O-t-Bu (129460-09-9,134098-70-7) → Ac-Tyr-Asp(CH2Cat)-Gly-Phe-CH2Cat (849367-11-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-diisopropylethylamine; HBTU / acetonitrile / 0.5 h

1.2: 72 percent / acetonitrile / 72 h

2.1: 85 percent / HCl / diethyl ether / 0.5 h

3.1: 18 percent / AlCl₃ / various solvent(s) / 0 °C

With hydrogenchloride; aluminium trichloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In diethyl ether; acetonitrile;

DOI:10.1055/s-2004-834914

upstream raw materials:

Ac-Tyr(tBu)-Asp(CH₂Ver)-Gly-Phe-CH₂Ver

2,3-dimethoxybenzyl amine

N-Fmoc L-Phe

Fmoc-Asp-O-t-Bu