3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene

Base Information

Chemical Name:3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene
CAS No.:1421036-67-0
Molecular Formula:C₃₅H₄₉F₅O₅Si
Molecular Weight:672.849
Hs Code.:

Synonyms:3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene

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Chemical Property of 3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene

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Technology Process of 3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene

There total 4 articles about 3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421036-66-9
3,3-ethylenedioxy-5α,10α-epoxy-17β-hydroxy-17-(1,1,2,2,2-pentafluoroethyl)-estra-9(11)-ene

: 87736-74-1
4-(tert-butyldimethylsiloxymethyl)bromobenzene

: 1421036-67-0
3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene

Guidance literature:: 4-(tert-butyldimethylsiloxymethyl)bromobenzene; With iodine; magnesium; In tetrahydrofuran; for 1.08333h; Reflux;

With copper(l) chloride; In tetrahydrofuran; at 0 ℃; for 0.5h;

3,3-ethylenedioxy-5α,10α-epoxy-17β-hydroxy-17-(1,1,2,2,2-pentafluoroethyl)-estra-9(11)-ene; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/j.steroids.2012.09.010

Reference yield:

: 5571-36-8
ethylene deltenone

: 1421036-67-0
3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: methyllithium lithium bromide / toluene; diethyl ether / 2.17 h / -78 - 0 °C

2.1: dihydrogen peroxide; Hexafluoroacetone; disodium hydrogenphosphate / dichloromethane / 0 - 5 °C

3.1: iodine; magnesium / tetrahydrofuran / 1.08 h / Reflux

3.2: 0.5 h / 0 °C

3.3: 2 h / 0 °C

With disodium hydrogenphosphate; methyllithium lithium bromide; dihydrogen peroxide; iodine; magnesium; Hexafluoroacetone; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.steroids.2012.09.010

Reference yield:

: 3,3-ethylenedioxy-17β-hydroxy-17-(1,1,2,2,2-pentafluoroethyl)-estra-5(10),9(11)-diene

: 1421036-67-0
3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]-estr-9-ene

Guidance literature:: Multi-step reaction with 2 steps

1.1: dihydrogen peroxide; Hexafluoroacetone; disodium hydrogenphosphate / dichloromethane / 0 - 5 °C

2.1: iodine; magnesium / tetrahydrofuran / 1.08 h / Reflux

2.2: 0.5 h / 0 °C

2.3: 2 h / 0 °C

With disodium hydrogenphosphate; dihydrogen peroxide; iodine; magnesium; Hexafluoroacetone; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.steroids.2012.09.010