17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one

Base Information

Chemical Name:17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one
CAS No.:1422259-33-3
Molecular Formula:C₂₈H₂₈F₈O₃
Molecular Weight:564.516
Hs Code.:

Synonyms:17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one

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Chemical Property of 17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one

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Technology Process of 17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one

There total 6 articles about 17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1421036-69-2
3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-(4'-formylphenyl)-estr-9-ene

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1422259-33-3
17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one

Guidance literature:: 3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-(4'-formylphenyl)-estr-9-ene; In tetrahydrofuran; at 0 ℃;

(trifluoromethyl)trimethylsilane; With sulfuric acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.steroids.2012.09.010

Reference yield:

: 5571-36-8
ethylene deltenone

: 1422259-33-3
17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: methyllithium lithium bromide / toluene; diethyl ether / 2.17 h / -78 - 0 °C

2.1: dihydrogen peroxide; Hexafluoroacetone; disodium hydrogenphosphate / dichloromethane / 0 - 5 °C

3.1: iodine; magnesium / tetrahydrofuran / 1.08 h / Reflux

3.2: 0.5 h / 0 °C

3.3: 2 h / 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 2 h / 20 °C / Molecular sieve

6.1: tetrahydrofuran / 0 °C

6.2: 0 - 20 °C

With disodium hydrogenphosphate; tetrapropylammonium perruthennate; methyllithium lithium bromide; tetrabutyl ammonium fluoride; dihydrogen peroxide; iodine; magnesium; 4-methylmorpholine N-oxide; Hexafluoroacetone; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.steroids.2012.09.010

Reference yield:

: 1421036-68-1
3,3-ethylenedioxy-5α,17β-dihydroxy-17-(1,1,2,2,2-pentafluoroethyl)-11β-[4'-(hydroxymethyl)phenyl]-estr-9-ene

: 1422259-33-3
17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-11β-{4'-[1'-hydroxy-2'2'2'-trifluoroethyl]phenyl}-estra-4,9-dien-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 2 h / 20 °C / Molecular sieve

2.1: tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.steroids.2012.09.010