4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide

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Chemical Name:4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide
CAS No.:486423-57-8
Molecular Formula:C₂₃H₂₅N₅O₃S
Molecular Weight:451.549
Hs Code.:

Synonyms:4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide

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Chemical Property of 4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide

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Technology Process of 4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide

There total 4 articles about 4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 486422-11-1
4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid

: 486422-99-5
2-amino-5-bromo-N-(3-pyridinyl)benzamide

: 486423-57-8
4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide

Guidance literature:: 4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid; 2-amino-5-bromo-N-(3-pyridinyl)benzamide; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; water; at 160 ℃; for 0.166667h; Microwave irradiation;

With hydrogenchloride; In methanol; dichloromethane;
DOI:10.1021/jm201724m

Reference yield:

: 837-12-7
1-((4-bromophenyl)sulfonyl)-4-methylpiperazine

: 486423-57-8
4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran / 18 h / -78 - 20 °C / Inert atmosphere

2: water; silica gel / tetrahydrofuran / 0.5 h

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 0.17 h / 160 °C / Microwave irradiation

With n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; silica gel; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 3: |Suzuki Coupling;
DOI:10.1021/jm201724m

Reference yield:

: C₁₇H₂₉BN₂O₄S

: 486423-57-8
4-amino-4'-[(4-methylpiperazin-1-yl)sulfonyl]-N-pyridin-3-yl-1,1'-biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; silica gel / tetrahydrofuran / 0.5 h

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 0.17 h / 160 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; silica gel; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2: |Suzuki Coupling;
DOI:10.1021/jm201724m