4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid

Base Information

• Chemical Name: 4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid
• CAS No.: 486422-11-1
• Molecular Formula: C11H17BN2O4S
• Molecular Weight: 284.144
• Mol file: 486422-11-1.mol

Synonyms:4-[(4-methylpiperazinyl)sulfonyl]phenylboronic acid;4-[(4-methyl-1-piperazinyl)sulfonyl]phenylboronic acid;4-(4-methylpiperazin-1-ylsulfonyl)phenylboronic acid;

Chemical Property of 4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid

Chemical Property:

• PSA: 89.46000
• LogP: -0.74090

Purity/Quality:

99% ，98% ^*data from raw suppliers

4-(4-Methyl-piperazinesulfonyl)phenylboronicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid

There total 4 articles about 4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-((4-bromophenyl)sulfonyl)-4-methylpiperazine (837-12-7) → 4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid (486422-11-1)

Guidance literature:

1-((4-bromophenyl)sulfonyl)-4-methylpiperazine; With n-butyllithium; In tetrahydrofuran; hexane; at 78 ℃; for 1h;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12.75h;

With water; sodium hydroxide; In tetrahydrofuran; hexane; for 12h;

Reference yield:

C17H29BN2O4S → 4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid (486422-11-1)

Guidance literature:

With water; silica gel; In tetrahydrofuran; for 0.5h;

DOI:10.1021/jm201724m

Reference yield:

1-methyl-piperazine (109-01-3) + 4-bromobenzenesulfonyl chloride (98-58-8) → 4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid (486422-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 78 °C

2.2: 12.75 h / -78 - 20 °C

2.3: 12 h

With n-butyllithium; In tetrahydrofuran; hexane;

upstream raw materials:

1-((4-bromophenyl)sulfonyl)-4-methylpiperazine

1-methyl-piperazine

4-bromobenzenesulfonyl chloride

Downstream raw materials:

2-(difluoromethyl)-4-methoxy-1-[4-{4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl}-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole

N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)quinazolin-4-amine

6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine

AZD₂₈₅₈

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