(R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione

Base Information

• Chemical Name: (R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione
• CAS No.: 725724-48-1
• Molecular Formula: C₃₄H₃₈N₄O₅
• Molecular Weight: 582.7
• Mol file: 725724-48-1.mol

Synonyms:(R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione

Chemical Property of (R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione

There total 1 articles about (R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-bromomethyl-3-methoxybenzene (874-98-6) + 1,4-bis[(4S,5R)-3,4-dimethyl-2-oxo-5-phenylimidazolidin-1-yl]butane-1,4-dione → (R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione (725724-48-1)

Guidance literature:

1,4-bis[(4S,5R)-3,4-dimethyl-2-oxo-5-phenylimidazolidin-1-yl]butane-1,4-dione; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

1-bromomethyl-3-methoxybenzene; In tetrahydrofuran; at -78 ℃; for 5h; Further stages.;

DOI:10.1016/j.tetlet.2004.04.008

Reference yield: 90.0%

(R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione (725724-48-1) → (2R)-2-(3-methoxybenzyl)succinic acid (338945-89-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; for 42h; Heating;

DOI:10.1016/j.tetlet.2004.04.008

Reference yield:

(R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione (725724-48-1) → (R)-4-<(3-methoxyphenyl)methyl>dihydro-2(3H)-furanone (77756-19-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / LiOH / tetrahydrofuran; H₂O / 42 h / Heating

2: 100 percent / Ac₂O / 0.17 h / 0 °C

3: 44 percent / NaBH₄ / tetrahydrofuran / 1 h / 0 - 5 °C

With lithium hydroxide; sodium tetrahydroborate; acetic anhydride; In tetrahydrofuran; water;

DOI:10.1016/j.tetlet.2004.04.008

upstream raw materials:

1-bromomethyl-3-methoxybenzene

Downstream raw materials:

(2R)-2-(3-methoxybenzyl)succinic acid

(R)-4-<(3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

(R)-3-(3-Methoxy-benzyl)-dihydro-furan-2,5-dione