(2R)-2-[(3-methoxyphenyl)methyl]butanedioic acid

Base Information

Chemical Name:(2R)-2-[(3-methoxyphenyl)methyl]butanedioic acid
CAS No.:338945-89-4
Molecular Formula:C₁₂H₁₄O₅
Molecular Weight:238.24
Hs Code.:
DSSTox Substance ID:DTXSID801236779
Nikkaji Number:J1.507.827H

Synonyms:(2R)-2-[(3-methoxyphenyl)methyl]butanedioic acid;DTXSID801236779;(R)-2-(3-Methoxybenzyl)succinic acid;338945-89-4

Suppliers and Price of (2R)-2-[(3-methoxyphenyl)methyl]butanedioic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-[(3-methoxyphenyl)methyl]butanedioic acid

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:238.08412354
Heavy Atom Count:17
Complexity:276

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1)CC(CC(=O)O)C(=O)O
Isomeric SMILES:COC1=CC=CC(=C1)C[C@H](CC(=O)O)C(=O)O

Technology Process of (2R)-2-[(3-methoxyphenyl)methyl]butanedioic acid

There total 5 articles about (2R)-2-[(3-methoxyphenyl)methyl]butanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 725724-48-1
(R)-1,4-Bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-(3-methoxy-benzyl)-butane-1,4-dione

: 338945-89-4
(2R)-2-(3-methoxybenzyl)succinic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; for 42h; Heating;
DOI:10.1016/j.tetlet.2004.04.008

Reference yield:

: 1145-50-2
2-(3-methoxybenzylidene)succinic acid

: 338945-89-4
(2R)-2-(3-methoxybenzyl)succinic acid

: (S)-2-(3-Methoxy-benzyl)-succinic acid

Guidance literature:: 2-(3-methoxybenzylidene)succinic acid; With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 7h;

optical resolution with (1R,2S)-2-(benzylamino)cyclohexylmethanol;
DOI:10.1248/cpb.49.340

Reference yield:

: 93578-34-8
2-[1-(3-Methoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester

: 338945-89-4
(2R)-2-(3-methoxybenzyl)succinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 5M aq. NaOH / methanol / Heating

2.1: H₂ / 10 percent Pd/C / ethanol / 7 h / 20 °C

2.2: optical resolution with (1R,2S)-2-(benzylamino)cyclohexylmethanol

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1248/cpb.49.340