(E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate

Base Information

• Chemical Name: (E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate
• CAS No.: 1256478-12-2
• Molecular Formula: C₂₄H₂₆N₂O₃S₂
• Molecular Weight: 454.614
• Mol file: 1256478-12-2.mol

Synonyms:(E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate

Chemical Property of (E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate

There total 6 articles about (E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-mercaptopentanoic acid hydrazide (98139-46-9) + C19H16O3S (1219077-43-6) → (E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate (1256478-12-2)

Guidance literature:

With acetic acid; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja106486b

Reference yield:

3-ethynyl-5-hydroxybenzaldehyde (871345-34-5) → (E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate (1256478-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 16 h / 20 °C

2.2: 3 h / 20 °C

3.1: acetic acid / methanol / 2 h / 20 °C / Inert atmosphere

With sodium hydride; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja106486b

Reference yield:

methyl 5-(acetylthio)pentanoate (116645-45-5) → (E)-S-3-((3-ethynyl-5-((2-(5-mercaptopentanoyl)hydrazono)methyl)phenoxy)methyl)benzylethanethioate (1256478-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / Inert atmosphere; Reflux

2: acetic acid / methanol / 2 h / 20 °C / Inert atmosphere

With hydrazine hydrate; acetic acid; In methanol;

DOI:10.1021/ja106486b

upstream raw materials:

3-ethynyl-5-hydroxybenzaldehyde

5-mercaptopentanoic acid hydrazide

C₁₉H₁₆O₃S

methyl 5-(acetylthio)pentanoate

Downstream raw materials:

C₄₃H₄₇N₅O₇S₄

C₄₁H₄₁N₅O₆S₄