Alfuzosin Hydrochloride

Base Information Edit

Chemical Name:Alfuzosin Hydrochloride
CAS No.:81403-68-1
Deprecated CAS:133880-44-1
Molecular Formula:C19H27N5O4^.HCl
Molecular Weight:425.915
Hs Code.:2934990002
European Community (EC) Number:620-512-3
UNII:75046A1XTN
DSSTox Substance ID:DTXSID3045514
Wikidata:Q27114856
NCI Thesaurus Code:C53408
RXCUI:46043
ChEMBL ID:CHEMBL1723
Mol file:81403-68-1.mol

Synonyms:Alfetim;alfusozine;alfuzosin;alfuzosin hydrochloride;alphuzosine;Benestan;N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide;Urion;UroXatral;Xatral

Suppliers and Price of Alfuzosin Hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Alfuzosin hydrochloride
10mg
$ 339.00

TRC
Alfuzosin Hydrochloride
25mg
$ 160.00

TRC
Alfuzosin Hydrochloride
50mg
$ 270.00

Tocris
Alfuzosin Hydrochloride ≥99%(HPLC)
50
$ 386.00

Tocris
Alfuzosin Hydrochloride ≥99%(HPLC)
10
$ 91.00

TCI Chemical
Alfuzosin Hydrochloride >98.0%(HPLC)
100mg
$ 56.00

TCI Chemical
Alfuzosin Hydrochloride >98.0%(HPLC)
1g
$ 252.00

Sigma-Aldrich
Alfuzosin hydrochloride European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Alfuzosin hydrochloride European Pharmacopoeia (EP) Reference Standard
a0325800
$ 190.00

Sigma-Aldrich
Alfuzosin for system suitability European Pharmacopoeia (EP) Reference Standard
y0000832
$ 190.00

Total 169 raw suppliers

Chemical Property of Alfuzosin Hydrochloride Edit

Chemical Property:

Appearance/Colour:White to off-white solid
Vapor Pressure:3.75E-19mmHg at 25°C
Melting Point:225 °C
Boiling Point:687.7 °C at 760 mmHg
PKA:8.13(at 25℃)
Flash Point:369.7 °C
PSA：111.83000
Density:1.272 g/cm3
LogP:3.12480
Storage Temp.:Store at RT
Solubility.:DMSO: >10mg/mL
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:425.1829821
Heavy Atom Count:29
Complexity:511

Purity/Quality:

99% ^*data from raw suppliers

Alfuzosin hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC.Cl
Recent ClinicalTrials:The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil
Recent EU Clinical Trials:Etude de l’efficacité et de la tolérance, de l’injection intra prostatique de toxine botulique A, chez l’homme, dans le traitement de l’hyperplasie bénigne de prostate symptomatique.
Description Alfuzosin (SL-77499) (I), a quinazoline derivative which is a uroselective alpha-1 adrenoreceptor antagonist, has been developed and launched worldwide by Sanofi-Synthelabo, for the treatment of benign prostate hyperplasia (BPH). In November 2003, alfuzosin (I) was launched as an extended release formulation in the US as Uroxatral utilizing Skyepharma’s oral controlled release technology.
Uses a-1- Adrenoceptor antagonist structurally similar to prozosin Antihypertensor;Alpha 1- adrenergic antagonist α1-Adrenoceptor antagonist structurally similar to Prozosin. Antihypertensive. Alfuzosin hydrochloride is used in treatment of benign prostatic hypertrophy.
Clinical Use Alpha-blocker: Treatment of benign prostatic hyperplasia Treatment of acute urinary retention
Drug interactions Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Antidepressants: enhanced hypotensive effect with MAOIs. Antivirals: concentration possibly increased by ritonavir - avoid; avoid with telaprevir. Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, separate administration by 4-6 hours. Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect. Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect. Cobicistat: concentration of alfuzosin possibly increased - avoid. Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect. Moxisylyte: possibly severe postural hypotension.

Technology Process of Alfuzosin Hydrochloride

There total 11 articles about Alfuzosin Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 81403-80-7
alfuzosin

: 81403-68-1
alfuzosin hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 20 - 25 ℃;

Reference yield: 87.5%

: N₁-(4-amino-6,7-dimethoxyquinazol-2-yl)-N₁-methyl-N₂-(tetrahydrofuro-2-yl)propylenediamine (7,7-dimethyl-2-oxo-bicyclo[2,2,1]hept-1-yl)methanesulfonate

: 81403-68-1
alfuzosin hydrochloride

Guidance literature:: N₁-(4-amino-6,7-dimethoxyquinazol-2-yl)-N₁-methyl-N₂-(tetrahydrofuro-2-yl)propylenediamine (7,7-dimethyl-2-oxo-bicyclo[2,2,1]hept-1-yl)methanesulfonate; With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 0.5h;

With hydrogenchloride; In ethanol; dichloromethane;