isopropyl 2-chloro-4-fluoro-5-iodobenzoate

Base Information

• Chemical Name: isopropyl 2-chloro-4-fluoro-5-iodobenzoate
• CAS No.: 431942-53-9
• Molecular Formula: C₁₀H₉ClFIO₂
• Molecular Weight: 342.536
• Mol file: 431942-53-9.mol

Synonyms:isopropyl 2-chloro-4-fluoro-5-iodobenzoate

Chemical Property of isopropyl 2-chloro-4-fluoro-5-iodobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of isopropyl 2-chloro-4-fluoro-5-iodobenzoate

There total 2 articles about isopropyl 2-chloro-4-fluoro-5-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methylethyl 5-amino-2-chloro-4-fluorobenzoate → isopropyl 2-chloro-4-fluoro-5-iodobenzoate (431942-53-9)

Guidance literature:

With concentrated hydrochloric acid; potassium iodide; urea; sodium nitrite; In dichloromethane; water;

Reference yield:

2-choro-4-fluorobenzoic acid (2252-51-9) → isopropyl 2-chloro-4-fluoro-5-iodobenzoate (431942-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodate; iodine / sulfuric acid / 8 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With sodium iodate; iodine; potassium carbonate; In sulfuric acid; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2016.08.021

Reference yield:

isopropyl 2-chloro-4-fluoro-5-iodobenzoate (431942-53-9) → isopropyl 2-chloro-4-fluoro-5-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)benzoate

Guidance literature:

Multi-step reaction with 5 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C

3.2: 1 h / -60 °C

4.1: hydrazine hydrate; copper diacetate / dichloromethane / 2 h / Reflux

5.1: toluene / 10 h / 80 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; hydrazine hydrate; tetrabutyl ammonium fluoride; copper diacetate; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 1.1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tet.2016.08.021

upstream raw materials:

2-choro-4-fluorobenzoic acid