Welcome to LookChem.com Sign In|Join Free

CAS

  • or

2252-51-9

Post Buying Request

2252-51-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

2252-51-9 Usage

Description

2-Chloro-4-fluorobenzoic acid is an organic compound characterized by its white powder or flake form. It features a benzene ring with a chlorine atom at the 2nd position and a fluorine atom at the 4th position, attached to a carboxyl group. This chemical structure endows it with specific properties that make it suitable for various applications across different industries.

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-fluorobenzoic acid is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of organic chemistry, 2-Chloro-4-fluorobenzoic acid serves as a valuable building block for the creation of more complex molecules. Its reactivity and functional groups make it a versatile compound for further chemical modifications and the synthesis of a wide range of products.
Used in Material Science:
The compound's properties also make it suitable for use in material science, where it can be employed in the development of new materials with specific characteristics, such as improved stability or enhanced chemical resistance.
Used in the Preparation of 2-(2-chloro-4-fluorophenyl)-benzothiazole:
Specifically, 2-Chloro-4-fluorobenzoic acid has been utilized in the preparation of 2-(2-chloro-4-fluorophenyl)-benzothiazole, a compound with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. The synthesis of this compound demonstrates the versatility and utility of 2-Chloro-4-fluorobenzoic acid in chemical research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 2252-51-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,5 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2252-51:
(6*2)+(5*2)+(4*5)+(3*2)+(2*5)+(1*1)=59
59 % 10 = 9
So 2252-51-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H4ClFO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,(H,10,11)/p-1

2252-51-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A14953)  2-Chloro-4-fluorobenzoic acid, 98%   

  • 2252-51-9

  • 5g

  • 295.0CNY

  • Detail
  • Alfa Aesar

  • (A14953)  2-Chloro-4-fluorobenzoic acid, 98%   

  • 2252-51-9

  • 25g

  • 1009.0CNY

  • Detail
  • Alfa Aesar

  • (A14953)  2-Chloro-4-fluorobenzoic acid, 98%   

  • 2252-51-9

  • 100g

  • 3428.0CNY

  • Detail

2252-51-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-4-fluorobenzoic acid

1.2 Other means of identification

Product number -
Other names 2-Cl-4-FHBA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2252-51-9 SDS

2252-51-9Synthetic route

4-amino-2-chlorobenzoic acid
2457-76-3

4-amino-2-chlorobenzoic acid

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

Conditions
ConditionsYield
Stage #1: 4-amino-2-chlorobenzoic acid With dihydrogen peroxide In water at 40 - 50℃; for 3h; Ionic liquid;
Stage #2: With potassium fluoride In water at 40 - 50℃; for 3h; Temperature;
97.5%
2-chloro-4-fluorotoluene
452-73-3

2-chloro-4-fluorotoluene

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

Conditions
ConditionsYield
With di-tert-butyl peroxide; hydrogen bromide; oxygen; cobalt(II) acetate; manganese(II) acetate In acetic acid at 130 - 160℃; under 15514.4 Torr; for 3h;92%
With potassium dichromate; sulfuric acid
2-chloro-4-fluorobenzaldehyde
84194-36-5

2-chloro-4-fluorobenzaldehyde

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium chlorite In water; acetonitrile at 0 - 80℃; for 1h;90.8%
carbon monoxide
201230-82-2

carbon monoxide

2-chloro-4-fluoro-1-iodobenzene
101335-11-9

2-chloro-4-fluoro-1-iodobenzene

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

Conditions
ConditionsYield
With water; palladium diacetate; triethylamine; triphenylphosphine In 1,4-dioxane at 110℃; under 11251.1 Torr; for 2h; Flow reactor;89%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

Conditions
ConditionsYield
With sodium hypobromide
3-chlorofluorobenzene
625-98-9

3-chlorofluorobenzene

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AlCl3 / CS2 / Heating
2: aq. sodium hypobromite
View Scheme
disodium hydrogenphosphate

disodium hydrogenphosphate

phenyl 2-chloro-4-fluorobenzoate
157165-30-5

phenyl 2-chloro-4-fluorobenzoate

2-chloro-4-fluoro-4'-methylbenzophenone

2-chloro-4-fluoro-4'-methylbenzophenone

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

Conditions
ConditionsYield
With sulfuric acid; acetic anhydride; urea In dichloromethane; water
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

2-chloro-4-fluoro-5-nitrobenzoic acid
114776-15-7

2-chloro-4-fluoro-5-nitrobenzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 0 - 10℃; for 2h;99%
Stage #1: 2-choro-4-fluorobenzoic acid With zirconium chloride; sulfuric acid; cobalt(II) chloride In ethanol; water at 25℃; for 1h;
Stage #2: With nitric acid In ethanol; water at -5 - 8℃; for 1h; Temperature;
97.1%
With sulfuric acid; nitric acid at 20℃; for 1h;96%
methanol
67-56-1

methanol

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

methyl 2-chloro-4-fluorobenzoate
85953-29-3

methyl 2-chloro-4-fluorobenzoate

Conditions
ConditionsYield
With chloro-trimethyl-silane at 20℃; for 24h;99%
With sulfuric acid at 60℃; for 17h;96%
With thionyl chloride95%
With sulfuric acid at 60℃; for 10h;92%
With sulfuric acid
4-Fluorophenol
371-41-5

4-Fluorophenol

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

4-fluoro-2-(4-fluorophenoxy)benzoic acid

4-fluoro-2-(4-fluorophenoxy)benzoic acid

Conditions
ConditionsYield
With pyridine; copper(l) iodide; copper; potassium carbonate In water for 2h; Heating / reflux;99%
With pyridine; copper(l) iodide; copper; potassium carbonate In water for 2h; Heating / reflux;99%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

2-chloro-4-fluoro-5-iodobenzoic acid
264927-52-8

2-chloro-4-fluoro-5-iodobenzoic acid

Conditions
ConditionsYield
With sodium iodate; iodine In sulfuric acid at 20℃; for 8h;99%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

2-chloro-4-fluoro-N-methoxy-N-methylbenzamide

2-chloro-4-fluoro-N-methoxy-N-methylbenzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 15℃; for 3h;98.66%
2-amino-benzthiazole
136-95-8

2-amino-benzthiazole

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

3-fluoro-12H-[1,3]benzothiazolo-[2,3-b]quinazolin-12-one

3-fluoro-12H-[1,3]benzothiazolo-[2,3-b]quinazolin-12-one

Conditions
ConditionsYield
With copper; potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.416667h; sonication;93%
With copper Ullmann condensation; Sonication;
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

N-t-Butyl-2-chloro-4-fluorobenzamide
223444-50-6

N-t-Butyl-2-chloro-4-fluorobenzamide

Conditions
ConditionsYield
93%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

2-(3-formyl-2-oxoquinolin-1(2H)-yl)acetohydrazide

2-(3-formyl-2-oxoquinolin-1(2H)-yl)acetohydrazide

1-((5-(2-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-1,2-dihydro-2-oxoquinoline-3-carbaldehyde

1-((5-(2-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-1,2-dihydro-2-oxoquinoline-3-carbaldehyde

Conditions
ConditionsYield
With trichlorophosphate at 110 - 120℃; Reflux;93%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

benzylamine
100-46-9

benzylamine

4-fluoro-N-benzylanthranilic acid
1002965-92-5

4-fluoro-N-benzylanthranilic acid

Conditions
ConditionsYield
With copper(I) oxide; copper; potassium carbonate In various solvent(s) at 130℃; for 24h;92%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

(2-chloro-4-fluorophenyl)methanol
208186-84-9

(2-chloro-4-fluorophenyl)methanol

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 20℃; for 2h;91.3%
pyrrolidine
123-75-1

pyrrolidine

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

4-fluoro-2-(1-pyrrolidinyl)benzoic acid

4-fluoro-2-(1-pyrrolidinyl)benzoic acid

Conditions
ConditionsYield
With copper; potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.25h; Ullmann condensation; ultrasonic irradiation;89%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

(2-Carboxy-6-fluorophenyl)propanedioic acid dimethyl ester

(2-Carboxy-6-fluorophenyl)propanedioic acid dimethyl ester

Conditions
ConditionsYield
With NaH; copper(I) bromide In water; mineral oil89%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

benzylamine
100-46-9

benzylamine

2-chloro-N-benzyl-4-fluorobenzamide
886624-05-1

2-chloro-N-benzyl-4-fluorobenzamide

Conditions
ConditionsYield
Stage #1: 2-choro-4-fluorobenzoic acid With triethylamine; isobutyl chloroformate In dichloromethane for 0.25h; Inert atmosphere; Schlenk technique;
Stage #2: benzylamine In dichloromethane at 0℃;
89%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

(E)-2-(tert-butyldiphenylsilyloxymethyl)-4-hydroxy-2-butenenitrile
639008-45-0

(E)-2-(tert-butyldiphenylsilyloxymethyl)-4-hydroxy-2-butenenitrile

2-chloro-4-fluoro-benzoic acid 4-(tert-butyl-diphenyl-silanyloxy)-3-cyano-but-2-enyl ester

2-chloro-4-fluoro-benzoic acid 4-(tert-butyl-diphenyl-silanyloxy)-3-cyano-but-2-enyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In toluene88%
propylamine
107-10-8

propylamine

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

4-fluoro-2-(propylamino)benzoic acid

4-fluoro-2-(propylamino)benzoic acid

Conditions
ConditionsYield
With copper; potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.416667h; Ullmann condensation; ultrasonic irradiation;87%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

4-chloro-3-[5-(trifluoromethyl)pyridin-2-yl]aniline

4-chloro-3-[5-(trifluoromethyl)pyridin-2-yl]aniline

2-chloro-N-{4-chloro-3-[5-(trifluoromethyl)pyridin-2-yl]phenyl}-4-fluorobenzamide

2-chloro-N-{4-chloro-3-[5-(trifluoromethyl)pyridin-2-yl]phenyl}-4-fluorobenzamide

Conditions
ConditionsYield
With 2-(7-azobenzotriazolyl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16h;86.4%
piperidine
110-89-4

piperidine

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

4-fluoro-2-(1-piperidinyl)benzoic acid
865471-09-6

4-fluoro-2-(1-piperidinyl)benzoic acid

Conditions
ConditionsYield
With copper; potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.25h; Ullmann condensation; ultrasonic irradiation;86%
1-(tert-butyl)-2-iodobenzene
62171-59-9

1-(tert-butyl)-2-iodobenzene

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

3-fluoro-9,9-dimethyl-9,10-dihydrophenanthrene

3-fluoro-9,9-dimethyl-9,10-dihydrophenanthrene

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine In N,N-dimethyl-formamide at 140℃; for 12h; Schlenk technique; Inert atmosphere;86%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

C7H4ClFO5S
714968-44-2

C7H4ClFO5S

Conditions
ConditionsYield
With chlorosulfonic acid at 150℃; for 6h;85%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

1-O-(2-chloro-4-fluorobenzoyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose

1-O-(2-chloro-4-fluorobenzoyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose

Conditions
ConditionsYield
With tetraethylammonium bromide; potassium carbonate In dichloromethane at 20℃; Molecular sieve;85%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

m-Anisidine
536-90-3

m-Anisidine

C14H12FNO3

C14H12FNO3

Conditions
ConditionsYield
With copper; potassium carbonate In pentan-1-ol at 20℃; for 5h; Reflux;85%
(S)-Leu-OMe
2666-93-5

(S)-Leu-OMe

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

methyl (2-chloro-4-fluorobenzoyl)-L-leucinate

methyl (2-chloro-4-fluorobenzoyl)-L-leucinate

Conditions
ConditionsYield
Stage #1: 2-choro-4-fluorobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃;
Stage #2: (S)-Leu-OMe In N,N-dimethyl-formamide at 0 - 20℃;
84%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

3,5-dimethylphenyl iodide
22445-41-6

3,5-dimethylphenyl iodide

3-chloro-5-fluoro-3',5'-dimethyl-1,1'-biphenyl
1344681-42-0

3-chloro-5-fluoro-3',5'-dimethyl-1,1'-biphenyl

Conditions
ConditionsYield
With palladium diacetate; acetic acid; silver carbonate at 130℃; for 16h; regioselective reaction;83%
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

methyl 2-(4-chloro-6-fluoro-3-oxo-1,3-dihydroisobenzofuran-1-yl)acetate

methyl 2-(4-chloro-6-fluoro-3-oxo-1,3-dihydroisobenzofuran-1-yl)acetate

Conditions
ConditionsYield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; oxygen; potassium hydrogencarbonate; acetic acid In 1,2-dichloro-ethane at 60℃; for 24h; Schlenk technique; Inert atmosphere;83%
morpholine
110-91-8

morpholine

2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

4-fluoro-2-(4-morpholinyl)benzoic acid

4-fluoro-2-(4-morpholinyl)benzoic acid

Conditions
ConditionsYield
With copper; potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.25h; Ullmann condensation; ultrasonic irradiation;82%
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2h;13%
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2h;
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

[1,1'-biphenyl]-2,2'-iodonium trifluoromethanesulfonate
189999-35-7

[1,1'-biphenyl]-2,2'-iodonium trifluoromethanesulfonate

2-fluorotriphenylene
439-23-6

2-fluorotriphenylene

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 12h;81%
With palladium diacetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 17h;81%

2252-51-9Relevant articles and documents

Stepwise benzylic oxygenation via uranyl-photocatalysis

Hu, Deqing,Jiang, Xuefeng

supporting information, p. 124 - 129 (2022/01/19)

Stepwise oxygenation at the benzylic position (1°, 2°, 3°) of aromatic molecules was comprehensively established under ambient conditions via uranyl photocatalysis to produce carboxylic acids, ketones, and alcohols, respectively. The accuracy of the stepwise oxygenation was ensured by the tunability of catalytic activity in uranyl photocatalysis, which was adjusted by solvents and additives demonstrated through Stern–Volmer analysis. Hydrogen atom transfer between the benzylic position and the uranyl catalyst facilitated oxygenation, further confirmed by kinetic studies. Considerably improved efficiency of flow operation demonstrated the potential for industrial synthetic application.

Flow carbonylation of sterically hindered ortho-substituted iodoarenes

Mallia, Carl J.,Walter, Gary C.,Baxendale, Ian R.

supporting information, p. 1503 - 1511 (2016/08/02)

The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse "tube-in-tube" flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.

INHIBITORS OF STEAROYL-COA DESATURASE

-

, (2009/06/27)

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2252-51-9