8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan

Base Information

• Chemical Name: 8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan
• CAS No.: 112999-84-5
• Molecular Formula: C₂₂H₃₆O₄
• Molecular Weight: 364.525
• Mol file: 112999-84-5.mol

Synonyms:8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan

Chemical Property of 8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan

There total 4 articles about 8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-(8-bromooctyloxy)tetrahydropyran (50816-20-1) + 1-methoxymethoxy-2-methylbenzene (55359-65-4) → 8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan (112999-84-5)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan (112999-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / pyridinium-p-toluenesulfonate / 12 h / Ambient temperature

2: 69 percent / 1.5 M BuLi, N,N,N',N'-tetramethylethylenediamine / hexane; tetrahydrofuran

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; pyridinium p-toluenesulfonate; In tetrahydrofuran; hexane;

Reference yield:

8-bromooctanol (50816-19-8) → 8-<2'-(Methoxymethoxy)-3'-methylphenyl>-1-<(RS)-2-tetrahydropyranyloxy>octan (112999-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / pyridinium-p-toluenesulfonate / 12 h / Ambient temperature

2: 69 percent / 1.5 M BuLi, N,N,N',N'-tetramethylethylenediamine / hexane; tetrahydrofuran

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; pyridinium p-toluenesulfonate; In tetrahydrofuran; hexane;

upstream raw materials:

2-(8-bromooctyloxy)tetrahydropyran

1-methoxymethoxy-2-methylbenzene

3,4-dihydro-2H-pyran

8-bromooctanol

Downstream raw materials:

8-(2'-hydroxy-3'-methylphenyl)-1-octanol