Technology Process of 2-bromo-1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone
There total 9 articles about 2-bromo-1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bromine;
In
chloroform;
for 2h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium carbonate / 2 h / Heating / reflux
2.1: iodine; silver nitrate / ethanol / 16 h / Heating / reflux
3.1: water / ethanol / 1.5 h / 90 °C
4.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C
5.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C
6.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h
6.2: 0.02 h
6.3: 1.5 h / 0 - 20 °C
7.1: sodium hydroxide; water / ethanol / 20 - 60 °C
8.1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C
9.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C
10.1: bromine / chloroform / 2 h / Heating / reflux
With
Lawessons reagent; 4-methyl-morpholine; sodium hydroxide; N-hydroxybenzotriazole ammonium salt; water; bromine; iodine; potassium carbonate; benzotriazol-1-ol; potassium hydrogencarbonate; silver nitrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; chloroform;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h
1.2: 0.02 h
1.3: 1.5 h / 0 - 20 °C
2.1: sodium hydroxide; water / ethanol / 20 - 60 °C
3.1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C
4.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C
5.1: bromine / chloroform / 2 h / Heating / reflux
With
4-methyl-morpholine; sodium hydroxide; water; bromine; benzotriazol-1-ol; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; chloroform;
![1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone](/Databaselist/images/loading.webp)
