1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone

Base Information

Chemical Name:1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone
CAS No.:913653-19-7
Molecular Formula:C₁₉H₁₆ClNO₂S
Molecular Weight:357.861
Hs Code.:

Synonyms:1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone

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Chemical Property of 1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone

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Technology Process of 1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone

There total 10 articles about 1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 913653-18-6
2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-methyl-N-(methyloxy)-1,3-thiazol-4-carboxamide

: 75-16-1
methylmagnesium bromide

: 913653-19-7
1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h;

Reference yield:

: 913651-21-5
2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboxylic acid

: 913653-19-7
1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C

2: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 1450-74-4
5-chloro-2-hydroxyacetophenone

: 913653-19-7
1-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]ethanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / 2 h / Heating / reflux

2.1: iodine; silver nitrate / ethanol / 16 h / Heating / reflux

3.1: water / ethanol / 1.5 h / 90 °C

4.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

5.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C

6.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h

6.2: 0.02 h

6.3: 1.5 h / 0 - 20 °C

7.1: sodium hydroxide; water / ethanol / 20 - 60 °C

8.1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C

9.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

With Lawessons reagent; 4-methyl-morpholine; sodium hydroxide; N-hydroxybenzotriazole ammonium salt; water; iodine; potassium carbonate; benzotriazol-1-ol; potassium hydrogencarbonate; silver nitrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane;