Technology Process of tert-butyl [(3R,4Z)-5-ethyl-3-methyl-4,6-heptadienyl]oxydiphenylsilane
There total 8 articles about tert-butyl [(3R,4Z)-5-ethyl-3-methyl-4,6-heptadienyl]oxydiphenylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: dimethylsulfide borane complex; dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 4 h / 0 °C
2: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C
3: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2.5 h / 0 - 20 °C
4: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C
5: sodium hydride / tetrahydrofuran / 1.5 h / -78 - 0 °C
6: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C
7: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C
8: n-butyllithium / tetrahydrofuran / 5 h / -78 - 0 °C
With
1H-imidazole; n-butyllithium; dimethylsulfide borane complex; water; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane;
5: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.tetlet.2011.05.151
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C
2: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2.5 h / 0 - 20 °C
3: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C
4: sodium hydride / tetrahydrofuran / 1.5 h / -78 - 0 °C
5: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C
6: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C
7: n-butyllithium / tetrahydrofuran / 5 h / -78 - 0 °C
With
1H-imidazole; n-butyllithium; water; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane;
4: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.tetlet.2011.05.151
