(R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Base Information

Chemical Name:(R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide
CAS No.:1600507-71-8
Molecular Formula:C₁₈H₂₁ClF₃N₅O₂S
Molecular Weight:463.911
Hs Code.:

Synonyms:(R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

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Chemical Property of (R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

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Technology Process of (R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

There total 8 articles about (R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.2%

: 1357098-11-3
4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carbaldehyde

: (R)-tert-butyl (5-(5-amino-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate

: 56553-60-7
sodium tris(acetoxy)borohydride

: 1600507-71-8
(R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: With acetic acid; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1600511-35-0
tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)thio)propan-2-yl)carbamate

: 1600507-71-8
(R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / methanol; dihydrogen peroxide; N,N-dimethyl-formamide; ethyl acetate

2: hydrogenchloride / 1,4-dioxane

3: sodium hydrogencarbonate / 1,4-dioxane

4: sodium azide / water; ethanol

5: water; tetrahydrofuran

6: trifluoroacetic acid; acetic acid / dichloromethane

With hydrogenchloride; sodium azide; sodium hydrogencarbonate; potassium carbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dihydrogen peroxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: (R)-tert-butyl (2-(5-bromo-2-fluorophenyl)-1-((2-cyanopropan-2-yl)sulfonyl)propan-2-yl)carbamate

: 1600507-71-8
(R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane

2: sodium hydrogencarbonate / 1,4-dioxane

3: sodium azide / water; ethanol

4: water; tetrahydrofuran

5: trifluoroacetic acid; acetic acid / dichloromethane

With hydrogenchloride; sodium azide; sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;