ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate

Base Information

Chemical Name:ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate
CAS No.:329076-23-5
Molecular Formula:C₂₂H₁₉FN₂O₅S
Molecular Weight:442.468
Hs Code.:

Synonyms:ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate

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Chemical Property of ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate

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Technology Process of ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate

There total 14 articles about ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 329076-76-8
ethyl 2-{(4-(4-fluorophenyl)-5-(4-(methylsulphonyl) phenyl)-1H-pyrazol-3-yl]oxy}-3-oxobutanoate

: 329076-23-5
ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In water; acetic acid; toluene; for 10h; Heating / reflux;

Reference yield:

: 587-88-2
ethyl 2-(4-fluorophenyl)acetate

: 329076-23-5
ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2: 95 percent / hydrazine hydrate; AcOH / dioxane; H₂O / 24 h / Heating

3: 90 percent / peracetic acid / CH₂Cl₂ / 4 h / 0 °C

4: 450 mg / K₂CO₃ / dimethylformamide / 9 h / 0 - 20 °C

5: 400 mg / p-TsOH*H₂O; AcOH / toluene / 10 h / Heating

With peracetic acid; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo049264k

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 329076-23-5
ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / H₂SO₄ / 8 h / Heating

2: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

3: 95 percent / hydrazine hydrate; AcOH / dioxane; H₂O / 24 h / Heating

4: 90 percent / peracetic acid / CH₂Cl₂ / 4 h / 0 °C

5: 450 mg / K₂CO₃ / dimethylformamide / 9 h / 0 - 20 °C

6: 400 mg / p-TsOH*H₂O; AcOH / toluene / 10 h / Heating

With peracetic acid; sulfuric acid; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo049264k