10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

Base Information

Chemical Name:10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine
CAS No.:142427-70-1
Molecular Formula:C₂₂H₂₄N₄O₂
Molecular Weight:376.458
Hs Code.:

Synonyms:10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

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Chemical Property of 10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

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Technology Process of 10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

There total 5 articles about 10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 541-41-3
chloroformic acid ethyl ester

: 142427-67-6
10,11-dihydro-11-benzylaminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

: 142427-70-1
10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1002/jhet.5570290233

Reference yield:

: 78105-30-3
5H-imidazo<2,1-c><1,4>benzodiazepine

: 142427-70-1
10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / ethanol / 12 h / 100 °C

2: 91 percent / H₂ / Raney-Ni / tetrahydrofuran; methanol; H₂O / 24 h / 8015.8 Torr

3: 94 percent / Et₃N / tetrahydrofuran / 1 h / 0 °C

4: 98 percent / LiAlH₄, concd. H₂SO₄ / tetrahydrofuran / 1 h / Ambient temperature

5: 98 percent / Et₃N / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; sulfuric acid; hydrogen; triethylamine; nickel; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1002/jhet.5570290233

Reference yield:

: 142427-60-9
10,11-dihydro-11-nitromethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

: 142427-70-1
10,11-dihydro-11-(N-ethoxycarbonyl-N-benzyl)aminomethyl-5H-imidazo<2,1-c><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / H₂ / Raney-Ni / tetrahydrofuran; methanol; H₂O / 24 h / 8015.8 Torr

2: 94 percent / Et₃N / tetrahydrofuran / 1 h / 0 °C

3: 98 percent / LiAlH₄, concd. H₂SO₄ / tetrahydrofuran / 1 h / Ambient temperature

4: 98 percent / Et₃N / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; sulfuric acid; hydrogen; triethylamine; nickel; In tetrahydrofuran; methanol; water;
DOI:10.1002/jhet.5570290233