(+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester

Base Information

Chemical Name:(+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester
CAS No.:369627-05-4
Molecular Formula:C₃₂H₄₄ClN₅O₈P₂
Molecular Weight:724.131
Hs Code.:

Synonyms:(+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester

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Technology Process of (+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester

There total 9 articles about (+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: phosphoric acid 2-(bis-benzyloxy-phosphanyloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)-propyl ester di-tert-butyl ester

: 369627-05-4
(+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at -78 - 20 ℃; for 0.666667h;
DOI:10.1021/jm010082h

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 369627-05-4
(+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole / tetrahydrofuran / 0.33 h / 20 °C

2: MCPBA / tetrahydrofuran / 0.67 h / -78 - 20 °C

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran;
DOI:10.1021/jm010082h

Reference yield:

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

: 369627-05-4
(+/-)-phosphoric acid dibenzyl ester 2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-(di-tert-butoxyphosphoryloxy)propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrazole / tetrahydrofuran / 0.33 h / 20 °C

2: MCPBA / tetrahydrofuran / 0.67 h / -78 - 20 °C

3: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

4: tetrazole / tetrahydrofuran / 0.33 h / 20 °C

5: MCPBA / tetrahydrofuran / 0.67 h / -78 - 20 °C

With 1H-tetrazole; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran;
DOI:10.1021/jm010082h