Di-tert-butyl N,N-diethylphosphoramidite

Base Information

Chemical Name:Di-tert-butyl N,N-diethylphosphoramidite
CAS No.:117924-33-1
Molecular Formula:C12H28NO2P
Molecular Weight:249.334
Hs Code.:29319090
European Community (EC) Number:627-954-6
DSSTox Substance ID:DTXSID10401241
Nikkaji Number:J1.433.907H
Wikidata:Q72470008
Mol file:117924-33-1.mol

Synonyms:di-tert-butyl diethylphosphoramidite

Suppliers and Price of Di-tert-butyl N,N-diethylphosphoramidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Di-t-butylN,N-Diethylphosphoramidite(~90%)
5g
$ 185.00

TRC
Di-t-butylN,N-Diethylphosphoramidite(~90%)
10g
$ 360.00

Sigma-Aldrich
Di-tert-butyl N,N-diethylphosphoramidite technical grade, 93%
5g
$ 260.00

Sigma-Aldrich
Di-tert-butyl N,N-diethylphosphoramidite technical grade, 93%
1g
$ 85.80

Medical Isotopes, Inc.
Di-t-butylN,N-Diethylphosphoramidite
25 g
$ 1720.00

Crysdot
Di-tert-butyldiethylphosphoramidite 90%
1g
$ 130.00

Crysdot
Di-tert-butyldiethylphosphoramidite 90%
5g
$ 280.00

Chemenu
Di-tert-butyl N,N-diethylphosphoramidite 95%+
100g
$ 467.00

Biosynth Carbosynth
Di-t-butyl N,N-diethylphosphoramidite
5 g
$ 500.00

Biosynth Carbosynth
Di-t-butyl N,N-diethylphosphoramidite
2 g
$ 250.00

Total 48 raw suppliers

Chemical Property of Di-tert-butyl N,N-diethylphosphoramidite

Chemical Property:

Appearance/Colour:Clear colourless liquid
Vapor Pressure:0.104mmHg at 25°C
Refractive Index:n20/D 1.434(lit.)
Boiling Point:221.963 °C at 760 mmHg
PKA:4.41±0.70(Predicted)
Flash Point:78.333 °C
PSA：35.29000
Density:0.896 g/mL at 25 °C(lit.)
LogP:4.18530
Storage Temp.:2-8°C
Sensitive.:Moisture Sensitive
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
Water Solubility.:Hydrolyzes in water. Soluble in chloroform and methanol.
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:249.18576613
Heavy Atom Count:16
Complexity:176

Purity/Quality:

99%, ^*data from raw suppliers

Di-t-butylN,N-Diethylphosphoramidite(~90%) ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)P(OC(C)(C)C)OC(C)(C)C
Uses A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists. Di-tert-butyl N,N-diethylphosphoramidite is a useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters.

Technology Process of Di-tert-butyl N,N-diethylphosphoramidite

There total 6 articles about Di-tert-butyl N,N-diethylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1069-08-5
diethylphosphoramidous dichloride

: 75-65-0
tert-butyl alcohol

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

Guidance literature:: With triethylamine; In diethyl ether; at 20 ℃; for 2h;

Reference yield: 55.0%

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

Guidance literature:

Reference yield:

: 15205-62-6
tri(tert-butyl)phosphite

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: PCl₃ / Heating

2: diethyl ether / 20 °C

With phosphorus trichloride; In diethyl ether;
DOI:10.1080/10426500008045253