(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester

Base Information

Chemical Name:(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester
CAS No.:910808-85-4
Molecular Formula:C₃₂H₃₂Cl₂IN₃O₆
Molecular Weight:752.433
Hs Code.:

Synonyms:(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester

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Technology Process of (R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester

There total 1 articles about (R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 910808-82-1
(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 910808-85-4
(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester

Guidance literature:: In methanol; benzene; at 20 ℃; for 24h;
DOI:10.1248/cpb.54.788

Reference yield: 39.0%

: tert-butoxycarbonylamino-(3-iodo-4-methoxy-5-tributylstannanyl-phenyl)-acetic acid methyl ester

: 910808-85-4
(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester

: (R,R,R)-2-(3-{7-[5-[(N-tert-butoxycarbonyl)(methoxycarbonyl)aminomethyl]-3-iodo-2-methoxyphenyl]indol-3-yl}-2-carbobenzyloxyaminopropionylamino)-2-(3,5-dichloro-4-methoxyphenyl)-acetic acid tert-butyl ester

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenyl-arsane; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1248/cpb.54.788

Reference yield:

: 910808-85-4
(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-methoxyphenylglycine tert-butyl ester

: (R)-((R)-3-{7-[5-(Amino-methoxycarbonyl-methyl)-3-iodo-2-methoxy-phenyl]-1H-indol-3-yl}-2-benzyloxycarbonylamino-propionylamino)-(3,5-dichloro-4-methoxy-phenyl)-acetic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / Pd₂(dba)3*CHCl₃; CuI; iPr₂NEt / Ph₃As / dimethylformamide / 2 h / 20 °C

2: 100 percent / CHCl₃ / 3.4 h / 0 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenyl-arsane; In chloroform; N,N-dimethyl-formamide; 1: Stille coupling;
DOI:10.1248/cpb.54.788