(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

Base Information

Chemical Name:(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester
CAS No.:910808-82-1
Molecular Formula:C₃₁H₃₀Cl₂IN₃O₆
Molecular Weight:738.406
Hs Code.:

Synonyms:(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

Suppliers and Price of (R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

There total 8 articles about (R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 872876-81-8
(R)-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

: 910808-60-5
(R)-N-carbobenzyloxy-7'-iodotryptophan

: 910808-82-1
(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

Guidance literature:: With pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 22h;
DOI:10.1248/cpb.54.788

Reference yield:

: 910808-44-5
N-formyl-7-iodoindoline

: 910808-82-1
(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / aq. NaOH / methanol / 0.5 h / 20 °C

2: 99 percent / salcomine; O₂ / methanol / 4 h

3: 84 percent / AcOH / 2.5 h / 75 °C

4: 45 percent / D-aminoacylase; CoCl₂*6H₂O / aq. phosphate buffer / 24 h / 37 °C / pH 7.4

5: 88 percent / aq. Na₂CO₃ / diethyl ether / 1.25 h / 0 °C

6: 56 percent / FDPP; iPr₂NEt; DIEA / tetrahydrofuran / 22 h / 20 °C

With sodium hydroxide; D-aminoacylase; salcomine; pentafluorophenyl diphenyl-phosphinate; oxygen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; cobalt(II) chloride; In tetrahydrofuran; methanol; phosphate buffer; diethyl ether;
DOI:10.1248/cpb.54.788

Reference yield:

: 910808-56-9
(R)-7'-iodotryphtophan

: 910808-82-1
(R,R)-7'-iodo-N-carbobenzyloxytryptophyl-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / aq. Na₂CO₃ / diethyl ether / 1.25 h / 0 °C

2: 56 percent / FDPP; iPr₂NEt; DIEA / tetrahydrofuran / 22 h / 20 °C

With pentafluorophenyl diphenyl-phosphinate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether;
DOI:10.1248/cpb.54.788