(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one

Base Information

Chemical Name:(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one
CAS No.:1361407-64-8
Molecular Formula:C₂₀H₂₇NO₅
Molecular Weight:361.438
Hs Code.:

Synonyms:(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one

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Chemical Property of (4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one

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Technology Process of (4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one

There total 3 articles about (4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1361407-61-5
(3R,4R)-4-[N-(tert-butoxycarbonyl)amino]-5-(4-methoxyphenyl)-2,3-dimethylpent-1-en-3-ol

: 1361407-64-8
(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one

Guidance literature:: (3R,4R)-4-[N-(tert-butoxycarbonyl)amino]-5-(4-methoxyphenyl)-2,3-dimethylpent-1-en-3-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1.5h; Inert atmosphere; Reflux;

di-tert-butyl dicarbonate; In tetrahydrofuran; mineral oil; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm2016914

Reference yield:

: 1275576-22-1
(R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

: 1361407-64-8
(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2.1: cerium(III) chloride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C / Inert atmosphere; Reflux

3.2: 2 h / 0 °C / Inert atmosphere

With cerium(III) chloride; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1021/jm2016914

Reference yield:

: C₁₆H₂₃NO₄

: 1361407-64-8
(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-5-(propen-2-yl)-1,3-oxazoli-din-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: cerium(III) chloride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C / Inert atmosphere; Reflux

2.2: 2 h / 0 °C / Inert atmosphere

With cerium(III) chloride; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1021/jm2016914