(R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

Base Information

Chemical Name:(R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide
CAS No.:1275576-22-1
Molecular Formula:C₁₇H₂₆N₂O₅
Molecular Weight:338.404
Hs Code.:

Synonyms:(R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

Suppliers and Price of (R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

Chemical Property:

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Technology Process of (R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

There total 1 articles about (R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 68856-96-2
N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine

: 1275576-22-1
(R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

Guidance literature:: N,O-dimethylhydroxylamine*hydrochloride; N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine; With 4-methyl-morpholine; In dichloromethane; at -15 ℃; for 0.0833333h; Inert atmosphere;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -15 - 20 ℃; for 5.5h; Inert atmosphere;
DOI:10.1021/jm101227t

Reference yield:

: 1275576-22-1
(R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

: 139183-60-1,120349-76-0
[(R)-1-Formyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: (R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at -33 - 0 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; at 20 ℃;
DOI:10.1021/jm101227t

Reference yield:

: 1275576-22-1
(R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

: 1361407-66-0
tert-butyl (E)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2.1: cerium(III) chloride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C / Inert atmosphere; Reflux

3.2: 2 h / 0 °C / Inert atmosphere

4.1: dimethylsulfide; ozone / ethyl acetate / 0.25 h / -78 - 0 °C

5.1: toluene / 10 h / Reflux

With cerium(III) chloride; dimethylsulfide; sodium hydride; ozone; In tetrahydrofuran; ethyl acetate; toluene; mineral oil; 5.1: Wittig reaction;
DOI:10.1021/jm2016914